Nitric oxide synthase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P29475. Use UniProt P29475 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29475 as the stable identity anchor, then attach disease evidence before program review.
Nitric oxide synthase 1
Review this target as Nitric oxide synthase 1, mapped to UniProt P29475. Sequence length is 1434 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nitric oxide synthase 1 as ChEMBL target CHEMBL3568, mapped to UniProt P29475. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nitric oxide synthase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P29475 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Nitric oxide synthase 1 |
| UniProt Accession | P29475 |
| Component Type | Protein |
| Sequence Length | 1434 aa |
Nitric oxide synthase 1
Review this target as Nitric oxide synthase 1, mapped to UniProt P29475. Sequence length is 1434 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL474637 | 10.07 | Ki | 0.085 | Preclinical |
| CHEMBL227937 | 9.82 | Ki | 0.15 | Preclinical |
| CHEMBL526688 | 9.6 | Ki | 0.25 | Preclinical |
| CHEMBL44833 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL510760 | 9.41 | Ki | 0.388 | Preclinical |
| CHEMBL106871 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL106871 | 9.0 | Kd | 1.0 | Preclinical |
| CHEMBL594682 | 8.28 | Ki | 5.3 | Preclinical |
| CHEMBL96680 | 8.22 | Ki | 6.0 | Preclinical |
| CHEMBL552825 | 8.2 | Ki | 6.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 115 | 786 | 5.8 |
| cell-based format | 28 | 271 | 6.1 |
| assay format | 24 | 181 | 6.9 |
| tissue-based format | 3 | 49 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |