Squalene--hopene cyclase · SINGLE PROTEIN · Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius)
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P33247. Use UniProt P33247 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P33247 as the stable identity anchor, then attach disease evidence before program review.
Squalene--hopene cyclase
Review this target as Squalene--hopene cyclase, mapped to UniProt P33247. Sequence length is 631 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Squalene--hopene cyclase as ChEMBL target CHEMBL3569, mapped to UniProt P33247. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Squalene--hopene cyclase |
| Target Type | SINGLE PROTEIN |
| Organism | Alicyclobacillus acidocaldarius subsp. acidocaldarius (strain ATCC27009 / DSM 446 / 104-1A) (Bacillus acidocaldarius) |
| UniProt | P33247 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Squalene--hopene cyclase |
| UniProt Accession | P33247 |
| Component Type | Protein |
| Sequence Length | 631 aa |
Squalene--hopene cyclase
Review this target as Squalene--hopene cyclase, mapped to UniProt P33247. Sequence length is 631 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL62855 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL65553 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL65230 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL292514 | 7.42 | IC50 | 38.0 | Preclinical |
| CHEMBL63524 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL65601 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL292084 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL293005 | 7.23 | IC50 | 59.0 | Preclinical |
| CHEMBL304858 | 7.22 | IC50 | 60.0 | Preclinical |
| CHEMBL63522 | 7.21 | IC50 | 62.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 8 | 4.6 |
| single protein format | 1 | 28 | 6.9 |