Cholesteryl ester transfer protein · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Cholesteryl ester transfer protein shows late clinical disease relevance led by Disorder of lipid metabolism. 5 more disease programs remain visible in the same review block. 6 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11597. Start with Disorder of lipid metabolism, then reuse UniProt P11597 as the stable protein anchor across project notes and exports.
Start with Disorder of lipid metabolism, then reuse UniProt P11597 as the stable protein anchor across project notes and exports.
Cholesteryl ester transfer protein shows late clinical disease relevance led by Disorder of lipid metabolism. 5 more disease programs remain visible in the same review block. 6 linked drugs remain visible in the same block.
Start review with Disorder of lipid metabolism because it currently carries late clinical support. Linked drugs include ANACETRAPIB, DALCETRAPIB, EVACETRAPIB, OBICETRAPIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCholesteryl ester transfer protein
Review this target as Cholesteryl ester transfer protein, mapped to UniProt P11597. Sequence length is 493 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cholesteryl ester transfer protein as ChEMBL target CHEMBL3572, mapped to UniProt P11597. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Cholesteryl ester transfer protein is the right protein anchor across sources, using UniProt P11597 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Disorder of lipid metabolism is currently framed as late clinical support. It currently carries 6 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Cholesteryl ester transfer protein |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11597 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cholesteryl ester transfer protein |
| UniProt Accession | P11597 |
| Component Type | Protein |
| Sequence Length | 493 aa |
Cholesteryl ester transfer protein
Review this target as Cholesteryl ester transfer protein, mapped to UniProt P11597. Sequence length is 493 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Cholesteryl ester transfer protein shows late clinical disease relevance led by Disorder of lipid metabolism. 5 more disease programs remain visible in the same review block.
Start review with Disorder of lipid metabolism because it currently carries late clinical support. Linked drugs include ANACETRAPIB, DALCETRAPIB, EVACETRAPIB, OBICETRAPIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL67129 | 9.11 | IC50 | 0.77 | Preclinical |
| CHEMBL2152167 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4439823 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3814374 | 8.89 | IC50 | 1.3 | Preclinical |
| CHEMBL3813720 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL3906320 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL3914103 | 8.8 | IC50 | 1.6 | Preclinical |
| CHEMBL3813836 | 8.74 | IC50 | 1.8 | Preclinical |
| CHEMBL3955558 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL3965631 | 8.72 | IC50 | 1.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 101 | 1,144 | 6.4 |
| cell-free format | 22 | 232 | 6.1 |
| cell-based format | 4 | 42 | 5.9 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 4 | 0 | — |
| cell-free format | 1 | 1 | 4.9 |