Programmed cell death 1 ligand 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Programmed cell death 1 ligand 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 13 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9NZQ7. Start with neoplasm, then reuse UniProt Q9NZQ7 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt Q9NZQ7 as the stable protein anchor across project notes and exports.
Programmed cell death 1 ligand 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 13 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ADEBRELIMAB, ATEZOLIZUMAB, AVELUMAB, BINTRAFUSP ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyProgrammed cell death 1 ligand 1
Review this target as Programmed cell death 1 ligand 1, mapped to UniProt Q9NZQ7. Sequence length is 290 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Programmed cell death 1 ligand 1 as ChEMBL target CHEMBL3580522, mapped to UniProt Q9NZQ7. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Programmed cell death 1 ligand 1 is the right protein anchor across sources, using UniProt Q9NZQ7 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 13 linked drugs in the same disease frame.
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| Preferred Name | Programmed cell death 1 ligand 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NZQ7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Programmed cell death 1 ligand 1 |
| UniProt Accession | Q9NZQ7 |
| Component Type | Protein |
| Sequence Length | 290 aa |
Programmed cell death 1 ligand 1
Review this target as Programmed cell death 1 ligand 1, mapped to UniProt Q9NZQ7. Sequence length is 290 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Programmed cell death 1 ligand 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include ADEBRELIMAB, ATEZOLIZUMAB, AVELUMAB, BINTRAFUSP ALFA. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4473436 | 10.72 | Kd | 0.019 | Preclinical |
| CHEMBL5412235 | 9.71 | Ki | 0.195 | Preclinical |
| CHEMBL4456990 | 9.7 | Kd | 0.2 | Preclinical |
| CHEMBL4578475 | 9.68 | Kd | 0.21 | Preclinical |
| CHEMBL5413429 | 9.68 | IC50 | 0.21 | Preclinical |
| CHEMBL4460716 | 9.54 | Kd | 0.29 | Preclinical |
| CHEMBL5398154 | 9.32 | IC50 | 0.48 | Preclinical |
| CHEMBL5207924 | 9.15 | Kd | 0.7 | Preclinical |
| CHEMBL4081869 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4776700 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 80 | 780 | 6.3 |
| cell-based format | 67 | 12 | 7.0 |
| assay format | 14 | 17 | 5.9 |
| subcellular format | 5 | 0 | — |
| tissue-based format | 2 | 1 | 7.3 |
| cell membrane format | 1 | 1 | 4.0 |