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Target Snapshot

CHEMBL3585 Target Snapshot

Sodium channel protein type 7 subunit alpha · SINGLE PROTEIN · Homo sapiens

96Compounds
21Assays
1Approved Drugs
111.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q01118. Use UniProt Q01118 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q01118 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Sodium channel protein type 7 subunit alpha as ChEMBL target CHEMBL3585, mapped to UniProt Q01118. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Sodium channel protein type 7 subunit alpha
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3585
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q01118
Sodium channel protein type 7 subunit alpha
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Sodium channel protein type 7 subunit alpha is the right protein anchor across sources, using UniProt Q01118 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium channel protein type 7 subunit alpha
UniProt AccessionQ01118
Component TypeProtein
Sequence Length1682 aa

Sodium channel protein type 7 subunit alpha

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Sodium channel protein type 7 subunit alpha, mapped to UniProt Q01118. Sequence length is 1682 aa.

Mapped IDQ01118
Review nameSodium channel protein type 7 subunit alpha
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
2
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50109.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4217988 11.0 IC50 0.01 Preclinical
CHEMBL3657855 9.4 IC50 0.4 Preclinical
CHEMBL3662190 9.22 IC50 0.6 Preclinical
CHEMBL5094715 9.22 IC50 0.6 Preclinical
CHEMBL3318132 9.1 IC50 0.8 Preclinical
CHEMBL5082131 9.1 IC50 0.8 Preclinical
CHEMBL4588728 9.05 IC50 0.9 Preclinical
CHEMBL3657932 8.96 IC50 1.1 Preclinical
CHEMBL3657851 8.8 IC50 1.6 Preclinical
CHEMBL5079176 8.74 IC50 1.8 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
23
5.5
14
6.0
7
6.5
15
7.0
10
7.5
8
8.0
9
8.5
7
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TETRACAINE
CHEMBL698
Approved 2005
Assay Landscape

Assay Landscape

21
Total Assays
88
Tested Compounds
1
Assay Types
Binding — 21 assays, 88 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 10 37 7.6
assay format 4 0
single protein format 3 2 8.1
subcellular format 3 0
cell membrane format 1 49 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine