Dual specificity mitogen-activated protein kinase kinase 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Dual specificity mitogen-activated protein kinase kinase 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 12 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q02750. Start with neoplasm, then reuse UniProt Q02750 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt Q02750 as the stable protein anchor across project notes and exports.
Dual specificity mitogen-activated protein kinase kinase 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 12 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AS-703988, AVUTOMETINIB, BINIMETINIB, COBIMETINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyDual specificity mitogen-activated protein kinase kinase 1
Review this target as Dual specificity mitogen-activated protein kinase kinase 1, mapped to UniProt Q02750. Sequence length is 393 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity mitogen-activated protein kinase kinase 1 as ChEMBL target CHEMBL3587, mapped to UniProt Q02750. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Dual specificity mitogen-activated protein kinase kinase 1 is the right protein anchor across sources, using UniProt Q02750 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 12 linked drugs in the same disease frame.
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| Preferred Name | Dual specificity mitogen-activated protein kinase kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q02750 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity mitogen-activated protein kinase kinase 1 |
| UniProt Accession | Q02750 |
| Component Type | Protein |
| Sequence Length | 393 aa |
Dual specificity mitogen-activated protein kinase kinase 1
Review this target as Dual specificity mitogen-activated protein kinase kinase 1, mapped to UniProt Q02750. Sequence length is 393 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Dual specificity mitogen-activated protein kinase kinase 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include AS-703988, AVUTOMETINIB, BINIMETINIB, COBIMETINIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3819302 | 10.82 | IC50 | 0.015 | Preclinical |
| CHEMBL3818677 | 10.72 | IC50 | 0.019 | Preclinical |
| CHEMBL2087076 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL1614766 | 9.62 | Kd | 0.24 | Preclinical |
| CHEMBL507361 | 9.48 | IC50 | 0.33 | Clinical |
| CHEMBL2087080 | 9.4 | EC50 | 0.4 | Preclinical |
| CHEMBL507361 | 9.4 | Kd | 0.4 | Clinical |
| CHEMBL2103875 | 9.32 | IC50 | 0.48 | Approved |
| CHEMBL3819622 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL2087461 | 9.22 | EC50 | 0.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 648 | 828 | 7.2 |
| cell-based format | 103 | 49 | 7.2 |
| assay format | 94 | 91 | 6.2 |
| subcellular format | 29 | 32 | 6.2 |
| organism-based format | 2 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 16 | 4 | 8.0 |
| assay format | 4 | 208 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |