Histone-lysine N-methyltransferase, H3 lysine-36 specific · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q96L73. Use UniProt Q96L73 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q96L73 as the stable identity anchor, then attach disease evidence before program review.
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Review this target as Histone-lysine N-methyltransferase, H3 lysine-36 specific, mapped to UniProt Q96L73. Sequence length is 2696 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone-lysine N-methyltransferase, H3 lysine-36 specific as ChEMBL target CHEMBL3588738, mapped to UniProt Q96L73. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Histone-lysine N-methyltransferase, H3 lysine-36 specific |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q96L73 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone-lysine N-methyltransferase, H3 lysine-36 specific |
| UniProt Accession | Q96L73 |
| Component Type | Protein |
| Sequence Length | 2696 aa |
Histone-lysine N-methyltransferase, H3 lysine-36 specific
Review this target as Histone-lysine N-methyltransferase, H3 lysine-36 specific, mapped to UniProt Q96L73. Sequence length is 2696 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL337173 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL5408212 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL5438312 | 6.67 | IC50 | 214.0 | Preclinical |
| CHEMBL5419719 | 6.65 | IC50 | 225.0 | Preclinical |
| CHEMBL5396709 | 6.61 | IC50 | 248.0 | Preclinical |
| CHEMBL5432302 | 6.57 | IC50 | 270.0 | Preclinical |
| CHEMBL5422549 | 6.16 | IC50 | 690.0 | Preclinical |
| CHEMBL5438496 | 5.92 | Kd | 1200.0 | Preclinical |
| CHEMBL554190 | 5.85 | Kd | 1400.0 | Preclinical |
| CHEMBL3137309 | 5.62 | IC50 | 2400.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 64 | 15 | 6.0 |
| cell-based format | 12 | 4 | 5.6 |
| assay format | 10 | 6 | 4.0 |