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Target Snapshot

CHEMBL3589 Target Snapshot

Adenosine kinase · SINGLE PROTEIN · Homo sapiens

874Compounds
169Assays
1Approved Drugs
1,100.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P55263. Use UniProt P55263 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P55263 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Adenosine kinase as ChEMBL target CHEMBL3589, mapped to UniProt P55263. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Adenosine kinase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3589
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P55263
Adenosine kinase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Adenosine kinase is the right protein anchor across sources, using UniProt P55263 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAdenosine kinase
UniProt AccessionP55263
Component TypeProtein
Sequence Length362 aa

Adenosine kinase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Adenosine kinase, mapped to UniProt P55263. Sequence length is 362 aa.

Mapped IDP55263
Review nameAdenosine kinase
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50826.0
KI40.0
KD234.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4460859 10.22 IC50 0.06 Preclinical
CHEMBL330432 10.0 IC50 0.1 Preclinical
CHEMBL370164 9.7 IC50 0.2 Preclinical
CHEMBL99707 9.7 IC50 0.2 Preclinical
CHEMBL194294 9.52 IC50 0.3 Preclinical
CHEMBL226486 9.4 IC50 0.4 Preclinical
CHEMBL343247 9.33 IC50 0.47 Preclinical
CHEMBL100421 9.3 IC50 0.5 Preclinical
CHEMBL370011 9.3 IC50 0.5 Preclinical
CHEMBL426472 9.3 IC50 0.5 Preclinical
Distribution

pChEMBL Value Distribution

59
5.0
52
5.5
85
6.0
90
6.5
102
7.0
61
7.5
60
8.0
37
8.5
30
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

169
Total Assays
496
Tested Compounds
3
Assay Types
Binding — 106 assays, 496 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 62 400 7.0
cell-based format 23 24 6.3
assay format 12 66 6.5
subcellular format 9 6 6.1
ADME — 57 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 48 0
single protein format 8 1 7.5
assay format 1 3 5.8
Functional — 6 assays, 53 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 52 6.5
assay format 2 0
subcellular format 1 1 8.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine