Hormone-sensitive lipase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q05469. Use UniProt Q05469 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q05469 as the stable identity anchor, then attach disease evidence before program review.
Hormone-sensitive lipase
Review this target as Hormone-sensitive lipase, mapped to UniProt Q05469. Sequence length is 1076 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hormone-sensitive lipase as ChEMBL target CHEMBL3590, mapped to UniProt Q05469. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Hormone-sensitive lipase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q05469 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hormone-sensitive lipase |
| UniProt Accession | Q05469 |
| Component Type | Protein |
| Sequence Length | 1076 aa |
Hormone-sensitive lipase
Review this target as Hormone-sensitive lipase, mapped to UniProt Q05469. Sequence length is 1076 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL106375 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL322794 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL419197 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL49895 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL107197 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL109116 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL110343 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4063082 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL3643710 | 8.62 | IC50 | 2.4 | Preclinical |
| CHEMBL106126 | 8.52 | IC50 | 3.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 15 | 276 | 7.0 |
| cell-based format | 7 | 32 | 7.2 |
| assay format | 3 | 9 | 5.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 62 | 7.2 |