Lanosterol synthase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P48449. Use UniProt P48449 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48449 as the stable identity anchor, then attach disease evidence before program review.
Lanosterol synthase
Review this target as Lanosterol synthase, mapped to UniProt P48449. Sequence length is 732 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Lanosterol synthase as ChEMBL target CHEMBL3593, mapped to UniProt P48449. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Lanosterol synthase is the right protein anchor across sources, using UniProt P48449 as the stable mapping.
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| Preferred Name | Lanosterol synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P48449 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lanosterol synthase |
| UniProt Accession | P48449 |
| Component Type | Protein |
| Sequence Length | 732 aa |
Lanosterol synthase
Review this target as Lanosterol synthase, mapped to UniProt P48449. Sequence length is 732 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL64905 | 9.66 | IC50 | 0.22 | Preclinical |
| CHEMBL542453 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL609978 | 8.72 | IC50 | 1.905 | Preclinical |
| CHEMBL63335 | 8.64 | IC50 | 2.3 | Preclinical |
| CHEMBL112210 | 8.54 | IC50 | 2.9 | Preclinical |
| CHEMBL67133 | 8.54 | IC50 | 2.884 | Preclinical |
| CHEMBL482527 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL63524 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL543877 | 8.46 | IC50 | 3.5 | Preclinical |
| CHEMBL65024 | 8.46 | IC50 | 3.467 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 26 | 94 | 7.3 |
| assay format | 11 | 51 | 6.3 |
| microsome format | 4 | 1 | 5.4 |
| cell-based format | 3 | 3 | 5.8 |
| tissue-based format | 1 | 28 | 7.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 6.4 |