3-hydroxy-3-methylglutaryl-coenzyme A reductase · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-13Protein identity stays anchored to UniProt Q1W675. Use UniProt Q1W675 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q1W675 as the stable identity anchor, then attach disease evidence before program review.
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Review this target as 3-hydroxy-3-methylglutaryl-coenzyme A reductase, mapped to UniProt Q1W675. Sequence length is 885 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 3-hydroxy-3-methylglutaryl-coenzyme A reductase as ChEMBL target CHEMBL3593154, mapped to UniProt Q1W675. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | Q1W675 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 3-hydroxy-3-methylglutaryl-coenzyme A reductase |
| UniProt Accession | Q1W675 |
| Component Type | Protein |
| Sequence Length | 885 aa |
3-hydroxy-3-methylglutaryl-coenzyme A reductase
Review this target as 3-hydroxy-3-methylglutaryl-coenzyme A reductase, mapped to UniProt Q1W675. Sequence length is 885 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1487 | 6.03 | IC50 | 930.0 | Approved |
| CHEMBL4204041 | 5.24 | IC50 | 5820.0 | Preclinical |
| CHEMBL4206214 | 5.21 | IC50 | 6210.0 | Preclinical |
| CHEMBL4215012 | 5.17 | IC50 | 6760.0 | Preclinical |
| CHEMBL4209384 | 5.13 | IC50 | 7430.0 | Preclinical |
| CHEMBL1915760 | 5.07 | IC50 | 8600.0 | Preclinical |
| CHEMBL4204038 | 5.05 | IC50 | 8900.0 | Preclinical |
| CHEMBL1099224 | 5.02 | IC50 | 9500.0 | Preclinical |
| CHEMBL3594152 | 4.97 | IC50 | 10700.0 | Preclinical |
| CHEMBL4096720 | 4.91 | IC50 | 12300.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 4 | 35 | 4.8 |