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Target Snapshot

CHEMBL3604 Target Snapshot

Protein kinase C gamma type · SINGLE PROTEIN · Rattus norvegicus

114Compounds
8Assays
0Approved Drugs
86.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P63319. Use UniProt P63319 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P63319 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein kinase C gamma type as ChEMBL target CHEMBL3604, mapped to UniProt P63319. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein kinase C gamma type
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL3604
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P63319
Protein kinase C gamma type
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein kinase C gamma type is the right protein anchor across sources, using UniProt P63319 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein kinase C gamma type
UniProt AccessionP63319
Component TypeProtein
Sequence Length697 aa

Protein kinase C gamma type

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein kinase C gamma type, mapped to UniProt P63319. Sequence length is 697 aa.

Mapped IDP63319
Review nameProtein kinase C gamma type
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5081.0
KI5.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL417692 8.7 Ki 2.0 Preclinical
CHEMBL538718 8.27 IC50 5.4 Preclinical
CHEMBL388978 8.05 IC50 9.0 Preclinical
CHEMBL26501 7.44 IC50 36.5 Preclinical
CHEMBL27768 7.28 Ki 52.9 Preclinical
CHEMBL51758 6.96 IC50 110.0 Preclinical
CHEMBL51708 6.77 IC50 170.0 Preclinical
CHEMBL53856 6.66 IC50 220.0 Preclinical
CHEMBL300479 6.55 IC50 280.0 Preclinical
CHEMBL301515 6.52 IC50 300.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
25
5.5
21
6.0
6
6.5
2
7.0
0
7.5
2
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
75
Tested Compounds
1
Assay Types
Binding — 8 assays, 75 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 5 73 5.8
cell-based format 2 0
single protein format 1 2 7.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine