Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9Z1L0. Use UniProt Q9Z1L0 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9Z1L0 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, mapped to UniProt Q9Z1L0. Sequence length is 1070 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform as ChEMBL target CHEMBL3608198, mapped to UniProt Q9Z1L0. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q9Z1L0 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform |
| UniProt Accession | Q9Z1L0 |
| Component Type | Protein |
| Sequence Length | 1070 aa |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform
Review this target as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform, mapped to UniProt Q9Z1L0. Sequence length is 1070 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1879463 | 8.0 | IC50 | 10.0 | Clinical |
| CHEMBL5174001 | 7.44 | IC50 | 36.0 | Preclinical |
| CHEMBL5175657 | 7.43 | IC50 | 37.0 | Preclinical |
| CHEMBL5177354 | 7.19 | IC50 | 65.0 | Preclinical |
| CHEMBL5203121 | 7.19 | IC50 | 65.0 | Preclinical |
| CHEMBL5181013 | 7.02 | IC50 | 96.0 | Preclinical |
| CHEMBL5173332 | 7.0 | IC50 | 101.0 | Preclinical |
| CHEMBL2017976 | 6.98 | IC50 | 104.0 | Preclinical |
| CHEMBL5188146 | 6.96 | IC50 | 109.0 | Preclinical |
| CHEMBL5181180 | 6.91 | IC50 | 124.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 45 | 6.2 |
| tissue-based format | 1 | 1 | 5.8 |