Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P13995. Use UniProt P13995 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P13995 as the stable identity anchor, then attach disease evidence before program review.
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Review this target as Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, mapped to UniProt P13995. Sequence length is 350 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial as ChEMBL target CHEMBL3621036, mapped to UniProt P13995. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial is the right protein anchor across sources, using UniProt P13995 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P13995 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial |
| UniProt Accession | P13995 |
| Component Type | Protein |
| Sequence Length | 350 aa |
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial
Review this target as Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial, mapped to UniProt P13995. Sequence length is 350 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4463968 | 8.2 | IC50 | 6.3 | Preclinical |
| CHEMBL4470947 | 8.03 | IC50 | 9.3 | Preclinical |
| CHEMBL4534641 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL4483030 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL297258 | 7.54 | Ki | 29.0 | Preclinical |
| CHEMBL4542665 | 7.48 | IC50 | 33.0 | Preclinical |
| CHEMBL4584730 | 7.43 | IC50 | 37.0 | Preclinical |
| CHEMBL4538356 | 7.42 | IC50 | 38.0 | Preclinical |
| CHEMBL4546647 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL4441993 | 7.31 | IC50 | 49.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 7 | 6.0 |
| single protein format | 4 | 39 | 6.3 |
| assay format | 1 | 1 | 6.2 |