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Target Snapshot

CHEMBL3623 Target Snapshot

NAD(P)H dehydrogenase [quinone] 1 · SINGLE PROTEIN · Homo sapiens

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985Compounds
275Assays
1Approved Drugs
310.0Activities
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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

NAD(P)H dehydrogenase [quinone] 1 shows late clinical disease relevance led by Friedreich ataxia. 5 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P15559. Start with Friedreich ataxia, then reuse UniProt P15559 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with Friedreich ataxia, then reuse UniProt P15559 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
Friedreich ataxia

NAD(P)H dehydrogenase [quinone] 1 shows late clinical disease relevance led by Friedreich ataxia. 5 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with Friedreich ataxia because it currently carries late clinical support. Linked drugs include VATIQUINONE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Late clinical Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NAD(P)H dehydrogenase [quinone] 1 as ChEMBL target CHEMBL3623, mapped to UniProt P15559. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NAD(P)H dehydrogenase [quinone] 1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3623
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P15559
NAD(P)H dehydrogenase [quinone] 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NAD(P)H dehydrogenase [quinone] 1 is the right protein anchor across sources, using UniProt P15559 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameNAD(P)H dehydrogenase [quinone] 1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP15559
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNAD(P)H dehydrogenase [quinone] 1
UniProt AccessionP15559
Component TypeProtein
Sequence Length274 aa

NAD(P)H dehydrogenase [quinone] 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NAD(P)H dehydrogenase [quinone] 1, mapped to UniProt P15559. Sequence length is 274 aa.

Mapped IDP15559
Review nameNAD(P)H dehydrogenase [quinone] 1
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Late clinical Open Targets-ready proxy

NAD(P)H dehydrogenase [quinone] 1 shows late clinical disease relevance led by Friedreich ataxia. 5 more disease programs remain visible in the same review block.

Late clinical Phase III
Friedreich ataxia
1 linked drug · 1 direct · 1 efficacy
Linked drugVATIQUINONE
Late clinical Phase III
mitochondrial disease
1 linked drug · 1 direct · 1 efficacy
Linked drugVATIQUINONE
Clinical signal Phase II
autism spectrum disorder
1 linked drug · 1 direct · 1 efficacy
Linked drugVATIQUINONE
Clinical signal Phase II
Leigh syndrome
1 linked drug · 1 direct · 1 efficacy
Linked drugVATIQUINONE
Clinical signal Phase II
noise-induced hearing loss
1 linked drug · 1 direct · 1 efficacy
Linked drugVATIQUINONE
Clinical signal Phase II
Parkinson disease
1 linked drug · 1 direct · 1 efficacy
Linked drugVATIQUINONE
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with Friedreich ataxia because it currently carries late clinical support. Linked drugs include VATIQUINONE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseFriedreich ataxia
Strongest levelLate clinical
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50220.0
KI1.0
EC5088.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL570570 9.74 IC50 0.18 Preclinical
CHEMBL571058 9.39 IC50 0.41 Preclinical
CHEMBL569640 9.38 IC50 0.42 Preclinical
CHEMBL569641 8.66 IC50 2.2 Preclinical
CHEMBL570349 8.6 IC50 2.5 Preclinical
CHEMBL1466 8.59 IC50 2.6 Approved
CHEMBL571496 8.55 IC50 2.8 Preclinical
CHEMBL576293 8.42 IC50 3.8 Preclinical
CHEMBL569406 8.35 IC50 4.5 Preclinical
CHEMBL568720 8.31 IC50 4.9 Preclinical
Distribution

pChEMBL Value Distribution

47
5.0
37
5.5
56
6.0
20
6.5
30
7.0
6
7.5
39
8.0
4
8.5
2
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

DICUMAROL
CHEMBL1466
Approved 1944
Properties Compare Identifier
Assay Landscape

Assay Landscape

275
Total Assays
217
Tested Compounds
3
Assay Types
Binding — 224 assays, 217 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 105 22 5.6
single protein format 104 114 6.0
assay format 15 81 6.9
ADME — 47 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 23 0 —
cell-based format 13 0 —
subcellular format 10 0 —
assay format 1 0 —
Functional — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine