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Target Snapshot

CHEMBL3632455 Target Snapshot

Probable G-protein coupled receptor 139 · SINGLE PROTEIN · Homo sapiens

379Compounds
19Assays
0Approved Drugs
953.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q6DWJ6. Use UniProt Q6DWJ6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q6DWJ6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Probable G-protein coupled receptor 139 as ChEMBL target CHEMBL3632455, mapped to UniProt Q6DWJ6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Probable G-protein coupled receptor 139
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3632455
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q6DWJ6
Probable G-protein coupled receptor 139
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Probable G-protein coupled receptor 139 is the right protein anchor across sources, using UniProt Q6DWJ6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProbable G-protein coupled receptor 139
UniProt AccessionQ6DWJ6
Component TypeProtein
Sequence Length353 aa

Probable G-protein coupled receptor 139

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Probable G-protein coupled receptor 139, mapped to UniProt Q6DWJ6. Sequence length is 353 aa.

Mapped IDQ6DWJ6
Review nameProbable G-protein coupled receptor 139
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Phase II
Assay Mix

Activity Type Distribution

KI355.0
EC50598.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4740228 9.0 EC50 1.0 Preclinical
CHEMBL4740491 9.0 EC50 1.0 Preclinical
CHEMBL4740519 9.0 EC50 1.0 Preclinical
CHEMBL4741806 9.0 EC50 1.0 Preclinical
CHEMBL4742673 9.0 EC50 1.0 Preclinical
CHEMBL4742901 9.0 EC50 1.0 Preclinical
CHEMBL4742949 9.0 EC50 1.0 Preclinical
CHEMBL4743199 9.0 EC50 1.0 Preclinical
CHEMBL4743612 9.0 EC50 1.0 Preclinical
CHEMBL4743662 9.0 EC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

22
5.0
45
5.5
69
6.0
96
6.5
139
7.0
119
7.5
62
8.0
0
8.5
129
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

19
Total Assays
297
Tested Compounds
2
Assay Types
Functional — 11 assays, 277 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 277 7.8
Binding — 8 assays, 297 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 66 8.7
assay format 2 73 6.3
cell membrane format 2 85 6.5
single protein format 1 73 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine