Use UniProt Q6DWJ6 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL3632455 Target Snapshot
Probable G-protein coupled receptor 139 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q6DWJ6. Use UniProt Q6DWJ6 as the stable identity anchor, then attach disease evidence before program review.
Probable G-protein coupled receptor 139
Review this target as Probable G-protein coupled receptor 139, mapped to UniProt Q6DWJ6. Sequence length is 353 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Probable G-protein coupled receptor 139 as ChEMBL target CHEMBL3632455, mapped to UniProt Q6DWJ6. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Probable G-protein coupled receptor 139 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6DWJ6 |
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UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Probable G-protein coupled receptor 139 |
| UniProt Accession | Q6DWJ6 |
| Component Type | Protein |
| Sequence Length | 353 aa |
Probable G-protein coupled receptor 139
How to read this target
Review this target as Probable G-protein coupled receptor 139, mapped to UniProt Q6DWJ6. Sequence length is 353 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4740228 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4740491 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4740519 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4741806 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4742673 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4742901 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4742949 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4743199 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4743612 | 9.0 | EC50 | 1.0 | Preclinical |
| CHEMBL4743662 | 9.0 | EC50 | 1.0 | Preclinical |
pChEMBL Value Distribution
Assay Landscape
Functional — 11 assays, 277 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 277 | 7.8 |
Binding — 8 assays, 297 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 66 | 8.7 |
| assay format | 2 | 73 | 6.3 |
| cell membrane format | 2 | 85 | 6.5 |
| single protein format | 1 | 73 | 6.5 |