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Target Snapshot

CHEMBL3636 Target Snapshot

Neuromedin-B receptor · SINGLE PROTEIN · Homo sapiens

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216Compounds
31Assays
0Approved Drugs
195.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P28336. Use UniProt P28336 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P28336 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neuromedin-B receptor as ChEMBL target CHEMBL3636, mapped to UniProt P28336. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neuromedin-B receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3636
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P28336
Neuromedin-B receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neuromedin-B receptor is the right protein anchor across sources, using UniProt P28336 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNeuromedin-B receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP28336
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeuromedin-B receptor
UniProt AccessionP28336
Component TypeProtein
Sequence Length390 aa

Neuromedin-B receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Neuromedin-B receptor, mapped to UniProt P28336. Sequence length is 390 aa.

Mapped IDP28336
Review nameNeuromedin-B receptor
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC5077.0
KI107.0
EC5011.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL403317 10.17 Ki 0.068 Preclinical
CHEMBL329650 9.82 Ki 0.15 Preclinical
CHEMBL5397144 9.81 EC50 0.1549 Preclinical
CHEMBL405908 9.77 Ki 0.17 Preclinical
CHEMBL327388 9.52 Ki 0.3 Preclinical
CHEMBL327840 9.49 Ki 0.32 Preclinical
CHEMBL86370 9.41 Ki 0.39 Preclinical
CHEMBL85400 9.36 Ki 0.44 Preclinical
CHEMBL312926 9.34 Ki 0.46 Preclinical
CHEMBL433143 9.28 Ki 0.52 Preclinical
Distribution

pChEMBL Value Distribution

27
5.0
23
5.5
23
6.0
21
6.5
5
7.0
6
7.5
8
8.0
10
8.5
12
9.0
4
9.5
pChEMBL
Assay Landscape

Assay Landscape

31
Total Assays
101
Tested Compounds
2
Assay Types
Binding — 18 assays, 101 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 98 6.2
single protein format 8 2 8.1
tissue-based format 1 1 9.2
Functional — 13 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 34 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine