Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL3638171 Target Snapshot

L-type calcium channel alpha 1C/beta 2A · PROTEIN COMPLEX · Oryctolagus cuniculus

Back to Search Search this target Browse approvals Evidence Card
2Compounds
2Assays
0Approved Drugs
2.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P15381. Use UniProt P15381 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P15381 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Voltage-dependent L-type calcium channel subunit alpha-1C

Voltage-dependent L-type calcium channel subunit alpha-1C

Review this target as L-type calcium channel alpha 1C/beta 2A, mapped to UniProt P15381. ChEMBL maps the protein component as Voltage-dependent L-type calcium channel subunit alpha-1C. Sequence length is 2171 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt P15381 Protein 2171 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats L-type calcium channel alpha 1C/beta 2A as ChEMBL target CHEMBL3638171, mapped to UniProt P15381. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
L-type calcium channel alpha 1C/beta 2A
PROTEIN COMPLEX · Oryctolagus cuniculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3638171
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P15381
Voltage-dependent L-type calcium channel subunit alpha-1C
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether L-type calcium channel alpha 1C/beta 2A is the right protein anchor across sources, using UniProt P15381 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameL-type calcium channel alpha 1C/beta 2A
Target TypePROTEIN COMPLEX
OrganismOryctolagus cuniculus
UniProtP15381
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelVoltage-dependent L-type calcium channel subunit alpha-1C
UniProt AccessionP15381
Component TypeProtein
Sequence Length2171 aa

Voltage-dependent L-type calcium channel subunit alpha-1C

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as L-type calcium channel alpha 1C/beta 2A, mapped to UniProt P15381. ChEMBL maps the protein component as Voltage-dependent L-type calcium channel subunit alpha-1C. Sequence length is 2171 aa.

Mapped IDP15381
Review nameL-type calcium channel alpha 1C/beta 2A
OrganismOryctolagus cuniculus
Assay Mix

Activity Type Distribution

IC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL98350 4.92 IC50 12000.0 Preclinical
CHEMBL261491 4.7 IC50 20000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
2
Tested Compounds
1
Assay Types
Functional — 2 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 2 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine