Genome polyprotein · SINGLE PROTEIN · Hepatitis C virus genotype 1a (isolate H) (HCV)
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Genome polyprotein shows clinical signal disease relevance led by hepatitis C virus infection. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P27958. Start with hepatitis C virus infection, then reuse UniProt P27958 as the stable protein anchor across project notes and exports.
Start with hepatitis C virus infection, then reuse UniProt P27958 as the stable protein anchor across project notes and exports.
Genome polyprotein shows clinical signal disease relevance led by hepatitis C virus infection. 1 linked drug remains visible in the same block.
Start review with hepatitis C virus infection because it currently carries clinical signal support. Linked drugs include MBL-HCV-1. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGenome polyprotein
Review this target as Genome polyprotein, mapped to UniProt P27958. Sequence length is 3011 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Genome polyprotein as ChEMBL target CHEMBL3638344, mapped to UniProt P27958. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Genome polyprotein is the right protein anchor across sources, using UniProt P27958 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hepatitis C virus infection is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Genome polyprotein |
| Target Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus genotype 1a (isolate H) (HCV) |
| UniProt | P27958 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Genome polyprotein |
| UniProt Accession | P27958 |
| Component Type | Protein |
| Sequence Length | 3011 aa |
Genome polyprotein
Review this target as Genome polyprotein, mapped to UniProt P27958. Sequence length is 3011 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Genome polyprotein shows clinical signal disease relevance led by hepatitis C virus infection.
Start review with hepatitis C virus infection because it currently carries clinical signal support. Linked drugs include MBL-HCV-1. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3645737 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL3645734 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3645741 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3953901 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3971537 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3939023 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL3645729 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL3645615 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL3645622 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL3909191 | 9.05 | IC50 | 0.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 768 | 6.9 |
| assay format | 4 | 350 | 8.1 |
| cell-free format | 1 | 17 | 8.1 |