Fibroblast growth factor receptor 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Fibroblast growth factor receptor 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 9 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P11362. Start with neoplasm, then reuse UniProt P11362 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt P11362 as the stable protein anchor across project notes and exports.
Fibroblast growth factor receptor 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 9 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include E-7090, FGFR INHIBITOR DEBIO 1347, HMPL-453, LUCITANIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyFibroblast growth factor receptor 1
Review this target as Fibroblast growth factor receptor 1, mapped to UniProt P11362. Sequence length is 822 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Fibroblast growth factor receptor 1 as ChEMBL target CHEMBL3650, mapped to UniProt P11362. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Fibroblast growth factor receptor 1 is the right protein anchor across sources, using UniProt P11362 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as approved-linked support. It currently carries 9 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
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| Preferred Name | Fibroblast growth factor receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P11362 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Fibroblast growth factor receptor 1 |
| UniProt Accession | P11362 |
| Component Type | Protein |
| Sequence Length | 822 aa |
Fibroblast growth factor receptor 1
Review this target as Fibroblast growth factor receptor 1, mapped to UniProt P11362. Sequence length is 822 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Fibroblast growth factor receptor 1 shows approved-linked disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries approved-linked support. Linked drugs include E-7090, FGFR INHIBITOR DEBIO 1347, HMPL-453, LUCITANIB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5951244 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL4870179 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL4862823 | 9.77 | IC50 | 0.17 | Preclinical |
| CHEMBL5556891 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL5177696 | 9.74 | IC50 | 0.18 | Preclinical |
| CHEMBL4557949 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4542061 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL4102642 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3827818 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3348846 | 9.7 | IC50 | 0.2 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 923 | 3,210 | 7.4 |
| assay format | 148 | 296 | 7.4 |
| cell-based format | 147 | 793 | 6.5 |
| subcellular format | 5 | 29 | 6.5 |
| organism-based format | 2 | 25 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 3 | 6.7 |
| assay format | 3 | 374 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 7 | 22 | 5.2 |
| single protein format | 5 | 16 | 7.1 |
| cell-based format | 1 | 0 | — |