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Target Snapshot

CHEMBL3658 Target Snapshot

Tubulin alpha chain · SINGLE PROTEIN · Sus scrofa

362Compounds
121Assays
4Approved Drugs
234.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P02550. Use UniProt P02550 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P02550 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Tubulin alpha chain as ChEMBL target CHEMBL3658, mapped to UniProt P02550. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Tubulin alpha chain
SINGLE PROTEIN · Sus scrofa
As of 2026-09-13
ChEMBL target ID
CHEMBL3658
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P02550
Tubulin alpha-1A chain
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Tubulin alpha chain is the right protein anchor across sources, using UniProt P02550 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTubulin alpha-1A chain
UniProt AccessionP02550
Component TypeProtein
Sequence Length451 aa

Tubulin alpha-1A chain

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Tubulin alpha chain, mapped to UniProt P02550. ChEMBL maps the protein component as Tubulin alpha-1A chain. Sequence length is 451 aa.

Mapped IDP02550
Review nameTubulin alpha chain
OrganismSus scrofa
Clinical Profile

Clinical Phase Distribution

4
Approved
3
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50227.0
KI7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL9652 7.92 IC50 12.0 Preclinical
CHEMBL56812 6.77 IC50 170.0 Preclinical
CHEMBL90555 6.66 IC50 220.0 Approved
CHEMBL418565 6.51 IC50 310.0 Preclinical
CHEMBL50826 6.44 IC50 363.08 Preclinical
CHEMBL50809 6.43 IC50 371.54 Preclinical
CHEMBL301589 6.42 IC50 380.19 Preclinical
CHEMBL15778 6.36 IC50 436.52 Preclinical
CHEMBL50139 6.35 IC50 446.68 Preclinical
CHEMBL61 6.34 IC50 460.0 Approved
Distribution

pChEMBL Value Distribution

47
5.0
65
5.5
46
6.0
3
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PODOFILOX
CHEMBL61
Approved 1990
VINCRISTINE
CHEMBL90555
Approved 1963
COLCHICINE
CHEMBL107
Approved 1961
Assay Landscape

Assay Landscape

121
Total Assays
141
Tested Compounds
2
Assay Types
Binding — 72 assays, 141 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 64 141 5.6
cell-based format 8 0
Functional — 49 assays, 46 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 49 46 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine