Glycogen synthase kinase-3 beta · SINGLE PROTEIN · Rattus norvegicus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P18266. Use UniProt P18266 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18266 as the stable identity anchor, then attach disease evidence before program review.
Glycogen synthase kinase-3 beta
Review this target as Glycogen synthase kinase-3 beta, mapped to UniProt P18266. Sequence length is 420 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Glycogen synthase kinase-3 beta as ChEMBL target CHEMBL3669, mapped to UniProt P18266. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Glycogen synthase kinase-3 beta |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P18266 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Glycogen synthase kinase-3 beta |
| UniProt Accession | P18266 |
| Component Type | Protein |
| Sequence Length | 420 aa |
Glycogen synthase kinase-3 beta
Review this target as Glycogen synthase kinase-3 beta, mapped to UniProt P18266. Sequence length is 420 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL50894 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL6291 | 8.17 | IC50 | 6.8 | Preclinical |
| CHEMBL361708 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL388978 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL336961 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL216543 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL296586 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL5280328 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL140 | 7.18 | IC50 | 66.0 | Clinical |
| CHEMBL323657 | 6.92 | IC50 | 120.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 3 | 6.7 |
| single protein format | 3 | 9 | 7.5 |
| assay format | 2 | 1 | 7.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |
| cell-based format | 1 | 16 | 5.7 |