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Target Snapshot

CHEMBL3681 Target Snapshot

Amine oxidase [flavin-containing] A · SINGLE PROTEIN · Mus musculus

460Compounds
25Assays
0Approved Drugs
55.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q64133. Use UniProt Q64133 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q64133 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Amine oxidase [flavin-containing] A as ChEMBL target CHEMBL3681, mapped to UniProt Q64133. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Amine oxidase [flavin-containing] A
SINGLE PROTEIN · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL3681
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q64133
Amine oxidase [flavin-containing] A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Amine oxidase [flavin-containing] A is the right protein anchor across sources, using UniProt Q64133 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelAmine oxidase [flavin-containing] A
UniProt AccessionQ64133
Component TypeProtein
Sequence Length526 aa

Amine oxidase [flavin-containing] A

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Amine oxidase [flavin-containing] A, mapped to UniProt Q64133. Sequence length is 526 aa.

Mapped IDQ64133
Review nameAmine oxidase [flavin-containing] A
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

3
Phase II
Assay Mix

Activity Type Distribution

IC5053.0
KI2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL307341 10.46 IC50 0.0346 Preclinical
CHEMBL8706 9.0 IC50 1.0 Clinical
CHEMBL5082735 8.11 IC50 7.8 Preclinical
CHEMBL121432 7.4 IC50 40.0 Preclinical
CHEMBL5084771 7.29 IC50 51.0 Preclinical
CHEMBL5420976 6.96 IC50 110.0 Preclinical
CHEMBL5402850 6.07 IC50 860.0 Preclinical
CHEMBL5440373 6.06 IC50 880.0 Preclinical
CHEMBL4162879 5.89 IC50 1300.0 Preclinical
CHEMBL5423568 5.75 IC50 1770.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
5
5.5
2
6.0
1
6.5
2
7.0
0
7.5
1
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

25
Total Assays
26
Tested Compounds
2
Assay Types
Binding — 17 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 6 6.0
single protein format 6 5 5.0
tissue-based format 4 5 5.5
cell-based format 1 10 6.2
Functional — 8 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 6 2 4.8
mitochondrion format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine