Autotaxin · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Autotaxin shows late clinical disease relevance led by idiopathic pulmonary fibrosis. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q13822. Start with idiopathic pulmonary fibrosis, then reuse UniProt Q13822 as the stable protein anchor across project notes and exports.
Start with idiopathic pulmonary fibrosis, then reuse UniProt Q13822 as the stable protein anchor across project notes and exports.
Autotaxin shows late clinical disease relevance led by idiopathic pulmonary fibrosis. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with idiopathic pulmonary fibrosis because it currently carries late clinical support. Linked drugs include ZIRITAXESTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyAutotaxin
Review this target as Autotaxin, mapped to UniProt Q13822. Sequence length is 863 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Autotaxin as ChEMBL target CHEMBL3691, mapped to UniProt Q13822. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Autotaxin is the right protein anchor across sources, using UniProt Q13822 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why idiopathic pulmonary fibrosis is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Autotaxin |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q13822 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Autotaxin |
| UniProt Accession | Q13822 |
| Component Type | Protein |
| Sequence Length | 863 aa |
Autotaxin
Review this target as Autotaxin, mapped to UniProt Q13822. Sequence length is 863 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Autotaxin shows late clinical disease relevance led by idiopathic pulmonary fibrosis. 2 more disease programs remain visible in the same review block.
Start review with idiopathic pulmonary fibrosis because it currently carries late clinical support. Linked drugs include ZIRITAXESTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3828074 | 11.0 | IC50 | 0.01 | Clinical |
| CHEMBL5183599 | 9.39 | IC50 | 0.41 | Preclinical |
| CHEMBL4640012 | 9.37 | IC50 | 0.43 | Preclinical |
| CHEMBL5766179 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5759407 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5742822 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4871014 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL4647222 | 9.0 | IC50 | 1.01 | Preclinical |
| CHEMBL3917975 | 9.0 | IC50 | 1.0 | Clinical |
| CHEMBL3828650 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 154 | 1,664 | 7.2 |
| cell-based format | 111 | 327 | 6.4 |
| cell-free format | 12 | 62 | 7.0 |
| assay format | 7 | 40 | 5.3 |
| tissue-based format | 5 | 11 | 7.4 |
| organism-based format | 1 | 27 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| organism-based format | 2 | 0 | — |