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Target Snapshot

CHEMBL3699 Target Snapshot

GABA transporter 4 · SINGLE PROTEIN · Mus musculus

635Compounds
92Assays
0Approved Drugs
731.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P31650. Use UniProt P31650 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P31650 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Protein anchor
Sodium- and chloride-dependent GABA transporter 3

Sodium- and chloride-dependent GABA transporter 3

Review this target as GABA transporter 4, mapped to UniProt P31650. ChEMBL maps the protein component as Sodium- and chloride-dependent GABA transporter 3. Sequence length is 627 aa.

Protein source · UniProt accession via ChEMBL component mapping
UniProt P31650 Protein 627 aa
Open protein block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats GABA transporter 4 as ChEMBL target CHEMBL3699, mapped to UniProt P31650. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
GABA transporter 4
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3699
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P31650
Sodium- and chloride-dependent GABA transporter 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether GABA transporter 4 is the right protein anchor across sources, using UniProt P31650 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSodium- and chloride-dependent GABA transporter 3
UniProt AccessionP31650
Component TypeProtein
Sequence Length627 aa

Sodium- and chloride-dependent GABA transporter 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as GABA transporter 4, mapped to UniProt P31650. ChEMBL maps the protein component as Sodium- and chloride-dependent GABA transporter 3. Sequence length is 627 aa.

Mapped IDP31650
Review nameGABA transporter 4
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC50730.0
KI1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4860085 5.89 IC50 1288.25 Preclinical
CHEMBL2403781 5.87 IC50 1348.96 Preclinical
CHEMBL75035 5.81 IC50 1548.82 Preclinical
CHEMBL4126078 5.78 IC50 1659.59 Preclinical
CHEMBL4779064 5.78 IC50 1659.59 Preclinical
CHEMBL419823 5.71 IC50 1949.84 Preclinical
CHEMBL4127466 5.67 IC50 2137.96 Preclinical
CHEMBL4781266 5.61 IC50 2454.71 Preclinical
CHEMBL4289242 5.55 IC50 2818.38 Preclinical
CHEMBL4278924 5.5 IC50 3162.28 Preclinical
Distribution

pChEMBL Value Distribution

110
5.0
26
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

92
Total Assays
382
Tested Compounds
2
Assay Types
Binding — 90 assays, 382 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 86 370 4.8
single protein format 4 12 5.2
ADME — 2 assays, 10 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 10 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine