Liver X receptor · PROTEIN FAMILY · Homo sapiens
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As of 2026-09-13Liver X receptor shows clinical signal disease relevance led by atopic eczema. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q13133. Start with atopic eczema, then reuse UniProt Q13133 as the stable protein anchor across project notes and exports.
Start with atopic eczema, then reuse UniProt Q13133 as the stable protein anchor across project notes and exports.
Liver X receptor shows clinical signal disease relevance led by atopic eczema. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with atopic eczema because it currently carries clinical signal support. Linked drugs include ROVAZOLAC. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyOxysterols receptor LXR-alpha
Review this target as Liver X receptor, mapped to UniProt Q13133. ChEMBL maps the protein component as Oxysterols receptor LXR-alpha. Sequence length is 447 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Liver X receptor as ChEMBL target CHEMBL3706564, mapped to UniProt Q13133. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Liver X receptor is the right protein anchor across sources, using UniProt Q13133 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why atopic eczema is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Liver X receptor |
| Target Type | PROTEIN FAMILY |
| Organism | Homo sapiens |
| UniProt | Q13133 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Oxysterols receptor LXR-alpha |
| UniProt Accession | Q13133 |
| Component Type | Protein |
| Sequence Length | 447 aa |
Oxysterols receptor LXR-alpha
Review this target as Liver X receptor, mapped to UniProt Q13133. ChEMBL maps the protein component as Oxysterols receptor LXR-alpha. Sequence length is 447 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Liver X receptor shows clinical signal disease relevance led by atopic eczema. 3 more disease programs remain visible in the same review block.
Start review with atopic eczema because it currently carries clinical signal support. Linked drugs include ROVAZOLAC. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3360966 | 9.32 | EC50 | 0.48 | Preclinical |
| CHEMBL3360975 | 8.92 | EC50 | 1.2 | Preclinical |
| CHEMBL3360973 | 8.51 | EC50 | 3.1 | Preclinical |
| CHEMBL3360974 | 8.49 | EC50 | 3.2 | Preclinical |
| CHEMBL3814206 | 8.4 | EC50 | 4.0 | Preclinical |
| CHEMBL3360970 | 8.3 | EC50 | 5.0 | Preclinical |
| CHEMBL3360961 | 8.15 | EC50 | 7.0 | Preclinical |
| CHEMBL3360972 | 8.15 | EC50 | 7.0 | Preclinical |
| CHEMBL3360965 | 8.1 | EC50 | 8.0 | Preclinical |
| CHEMBL3360971 | 8.08 | EC50 | 8.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 65 | 22 | 7.0 |
| protein format | 17 | 6 | 8.6 |
| assay format | 10 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 12 | 0 | — |
| assay format | 4 | 22 | 6.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 7 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 5 | 0 | — |