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Target Snapshot

CHEMBL3706570 Target Snapshot

MOLM-14 · CELL-LINE · Homo sapiens

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198Compounds
233Assays
5Approved Drugs
212.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats MOLM-14 as ChEMBL target CHEMBL3706570. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
MOLM-14
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3706570
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether MOLM-14 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMOLM-14
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMOLM-14
UniProt AccessionN/A

MOLM-14

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as MOLM-14.

Review nameMOLM-14
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
3
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50204.0
EC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5170277 9.89 IC50 0.13 Preclinical
CHEMBL5569019 9.72 IC50 0.19 Preclinical
CHEMBL5589647 9.51 IC50 0.31 Preclinical
CHEMBL5284731 9.3 IC50 0.5 Preclinical
CHEMBL5563397 9.29 IC50 0.51 Preclinical
CHEMBL4555872 9.22 IC50 0.6 Preclinical
CHEMBL5269280 9.14 IC50 0.72 Preclinical
CHEMBL5572898 9.11 IC50 0.77 Preclinical
CHEMBL5573225 9.06 IC50 0.87 Preclinical
CHEMBL5591269 9.0 IC50 1.0 Preclinical
Distribution

pChEMBL Value Distribution

8
5.0
6
5.5
23
6.0
27
6.5
32
7.0
27
7.5
32
8.0
16
8.5
10
9.0
3
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACRITINIB
CHEMBL2035187
Approved 2022
Properties Compare Identifier
PEXIDARTINIB
CHEMBL3813873
Approved 2019
Properties Compare Identifier
GILTERITINIB
CHEMBL3301622
Approved 2018
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

233
Total Assays
96
Tested Compounds
1
Assay Types
Functional — 233 assays, 96 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 225 96 7.3
organism-based format 8 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine