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Target Snapshot

CHEMBL3712907 Target Snapshot

Transmembrane domain-containing protein TMIGD3 · SINGLE PROTEIN · Homo sapiens

183Compounds
27Assays
1Approved Drugs
164.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0DMS9. Use UniProt P0DMS9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0DMS9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Transmembrane domain-containing protein TMIGD3 as ChEMBL target CHEMBL3712907, mapped to UniProt P0DMS9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Transmembrane domain-containing protein TMIGD3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3712907
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0DMS9
Transmembrane domain-containing protein TMIGD3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Transmembrane domain-containing protein TMIGD3 is the right protein anchor across sources, using UniProt P0DMS9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTransmembrane domain-containing protein TMIGD3
UniProt AccessionP0DMS9
Component TypeProtein
Sequence Length266 aa

Transmembrane domain-containing protein TMIGD3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Transmembrane domain-containing protein TMIGD3, mapped to UniProt P0DMS9. Sequence length is 266 aa.

Mapped IDP0DMS9
Review nameTransmembrane domain-containing protein TMIGD3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC506.0
KI153.0
EC503.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3747303 9.27 Ki 0.54 Preclinical
CHEMBL3746778 9.24 Ki 0.58 Preclinical
CHEMBL3746260 9.16 Ki 0.69 Preclinical
CHEMBL3612943 9.14 Ki 0.73 Preclinical
CHEMBL3747005 9.07 Ki 0.85 Preclinical
CHEMBL3747209 9.07 Ki 0.85 Preclinical
CHEMBL3746512 9.04 Ki 0.91 Preclinical
CHEMBL3746358 9.02 Ki 0.96 Preclinical
CHEMBL3746774 9.02 Ki 0.95 Preclinical
CHEMBL3747276 9.02 Ki 0.96 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
24
5.5
22
6.0
28
6.5
18
7.0
12
7.5
12
8.0
12
8.5
10
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

27
Total Assays
148
Tested Compounds
1
Assay Types
Binding — 27 assays, 148 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 146 6.8
single protein format 6 2 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine