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Target Snapshot

CHEMBL3712947 Target Snapshot

Na(+)/dicarboxylate cotransporter 3 · SINGLE PROTEIN · Homo sapiens

7Compounds
4Assays
0Approved Drugs
7.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q8WWT9. Use UniProt Q8WWT9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q8WWT9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Na(+)/dicarboxylate cotransporter 3 as ChEMBL target CHEMBL3712947, mapped to UniProt Q8WWT9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Na(+)/dicarboxylate cotransporter 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3712947
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q8WWT9
Na(+)/dicarboxylate cotransporter 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Na(+)/dicarboxylate cotransporter 3 is the right protein anchor across sources, using UniProt Q8WWT9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNa(+)/dicarboxylate cotransporter 3
UniProt AccessionQ8WWT9
Component TypeProtein
Sequence Length602 aa

Na(+)/dicarboxylate cotransporter 3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Na(+)/dicarboxylate cotransporter 3, mapped to UniProt Q8WWT9. Sequence length is 602 aa.

Mapped IDQ8WWT9
Review nameNa(+)/dicarboxylate cotransporter 3
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC505.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5405434 6.8 IC50 160.0 Preclinical
CHEMBL3771118 5.0 IC50 10000.0 Preclinical
CHEMBL1686 4.27 EC50 54000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
0
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
2
Tested Compounds
2
Assay Types
Binding — 3 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 2 5.5
single protein format 1 0
Functional — 1 assays, 2 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 2 4.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine