Inducible T-cell costimulator · SINGLE PROTEIN · Homo sapiens
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Inducible T-cell costimulator shows clinical signal disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt Q9Y6W8. Start with neoplasm, then reuse UniProt Q9Y6W8 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt Q9Y6W8 as the stable protein anchor across project notes and exports.
Inducible T-cell costimulator shows clinical signal disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include FELADILIMAB, VOPRATELIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyInducible T-cell costimulator
Review this target as Inducible T-cell costimulator, mapped to UniProt Q9Y6W8. Sequence length is 199 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Inducible T-cell costimulator as ChEMBL target CHEMBL3712953, mapped to UniProt Q9Y6W8. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Inducible T-cell costimulator is the right protein anchor across sources, using UniProt Q9Y6W8 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Inducible T-cell costimulator |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9Y6W8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Inducible T-cell costimulator |
| UniProt Accession | Q9Y6W8 |
| Component Type | Protein |
| Sequence Length | 199 aa |
Inducible T-cell costimulator
Review this target as Inducible T-cell costimulator, mapped to UniProt Q9Y6W8. Sequence length is 199 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Inducible T-cell costimulator shows clinical signal disease relevance led by neoplasm. 5 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include FELADILIMAB, VOPRATELIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5590462 | 5.35 | Kd | 4470.0 | Preclinical |
| CHEMBL5591374 | 4.43 | Kd | 36700.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 2 | 4.9 |