Tissue factor pathway inhibitor · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Tissue factor pathway inhibitor shows approved-linked disease relevance led by hemophilia A. 4 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P10646. Start with hemophilia A, then reuse UniProt P10646 as the stable protein anchor across project notes and exports.
Start with hemophilia A, then reuse UniProt P10646 as the stable protein anchor across project notes and exports.
Tissue factor pathway inhibitor shows approved-linked disease relevance led by hemophilia A. 4 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with hemophilia A because it currently carries approved-linked support. Linked drugs include BAY-1093884, CONCIZUMAB, MARSTACIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyTissue factor pathway inhibitor
Review this target as Tissue factor pathway inhibitor, mapped to UniProt P10646. Sequence length is 304 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tissue factor pathway inhibitor as ChEMBL target CHEMBL3713062, mapped to UniProt P10646. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Tissue factor pathway inhibitor is the right protein anchor across sources, using UniProt P10646 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hemophilia A is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Tissue factor pathway inhibitor |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P10646 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tissue factor pathway inhibitor |
| UniProt Accession | P10646 |
| Component Type | Protein |
| Sequence Length | 304 aa |
Tissue factor pathway inhibitor
Review this target as Tissue factor pathway inhibitor, mapped to UniProt P10646. Sequence length is 304 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Tissue factor pathway inhibitor shows approved-linked disease relevance led by hemophilia A. 4 more disease programs remain visible in the same review block.
Start review with hemophilia A because it currently carries approved-linked support. Linked drugs include BAY-1093884, CONCIZUMAB, MARSTACIMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4545581 | 10.27 | Kd | 0.054 | Preclinical |
| CHEMBL4543933 | 10.22 | EC50 | 0.06 | Preclinical |
| CHEMBL3894172 | 9.52 | Kd | 0.3 | Preclinical |
| CHEMBL4473203 | 9.47 | IC50 | 0.337 | Preclinical |
| CHEMBL4447126 | 9.25 | IC50 | 0.56 | Preclinical |
| CHEMBL4544981 | 9.24 | IC50 | 0.57 | Preclinical |
| CHEMBL4515587 | 9.24 | IC50 | 0.58 | Preclinical |
| CHEMBL4467258 | 9.24 | IC50 | 0.57 | Preclinical |
| CHEMBL4570697 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL4450425 | 9.21 | IC50 | 0.61 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 99 | 1,580 | 6.5 |
| cell-free format | 28 | 49 | 6.2 |
| cell-based format | 5 | 0 | — |
| assay format | 1 | 0 | — |