G-protein coupled receptor 84 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14G-protein coupled receptor 84 shows clinical signal disease relevance led by Alstrom syndrome. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q9NQS5. Start with Alstrom syndrome, then reuse UniProt Q9NQS5 as the stable protein anchor across project notes and exports.
Start with Alstrom syndrome, then reuse UniProt Q9NQS5 as the stable protein anchor across project notes and exports.
G-protein coupled receptor 84 shows clinical signal disease relevance led by Alstrom syndrome. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Alstrom syndrome because it currently carries clinical signal support. Linked drugs include SETOGEPRAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyG-protein coupled receptor 84
Review this target as G-protein coupled receptor 84, mapped to UniProt Q9NQS5. Sequence length is 396 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats G-protein coupled receptor 84 as ChEMBL target CHEMBL3714079, mapped to UniProt Q9NQS5. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether G-protein coupled receptor 84 is the right protein anchor across sources, using UniProt Q9NQS5 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Alstrom syndrome is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
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| Preferred Name | G-protein coupled receptor 84 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q9NQS5 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | G-protein coupled receptor 84 |
| UniProt Accession | Q9NQS5 |
| Component Type | Protein |
| Sequence Length | 396 aa |
G-protein coupled receptor 84
Review this target as G-protein coupled receptor 84, mapped to UniProt Q9NQS5. Sequence length is 396 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
G-protein coupled receptor 84 shows clinical signal disease relevance led by Alstrom syndrome. 3 more disease programs remain visible in the same review block.
Start review with Alstrom syndrome because it currently carries clinical signal support. Linked drugs include SETOGEPRAM. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3714783 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714785 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714806 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714875 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714891 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714904 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714917 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714918 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714958 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3714986 | 11.0 | IC50 | 0.01 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 107 | 607 | 7.6 |
| cell membrane format | 7 | 117 | 6.7 |
| assay format | 2 | 91 | 10.4 |
| tissue-based format | 2 | 1 | 8.1 |
| single protein format | 1 | 1 | 6.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 36 | 100 | 6.7 |
| single protein format | 3 | 2 | 5.0 |
| cell membrane format | 1 | 1 | 9.6 |