Palmitoleoyl-protein carboxylesterase NOTUM · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q6P988. Use UniProt Q6P988 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q6P988 as the stable identity anchor, then attach disease evidence before program review.
Palmitoleoyl-protein carboxylesterase NOTUM
Review this target as Palmitoleoyl-protein carboxylesterase NOTUM, mapped to UniProt Q6P988. Sequence length is 496 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Palmitoleoyl-protein carboxylesterase NOTUM as ChEMBL target CHEMBL3714531, mapped to UniProt Q6P988. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Palmitoleoyl-protein carboxylesterase NOTUM is the right protein anchor across sources, using UniProt Q6P988 as the stable mapping.
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| Preferred Name | Palmitoleoyl-protein carboxylesterase NOTUM |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q6P988 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Palmitoleoyl-protein carboxylesterase NOTUM |
| UniProt Accession | Q6P988 |
| Component Type | Protein |
| Sequence Length | 496 aa |
Palmitoleoyl-protein carboxylesterase NOTUM
Review this target as Palmitoleoyl-protein carboxylesterase NOTUM, mapped to UniProt Q6P988. Sequence length is 496 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4796694 | 10.29 | IC50 | 0.051 | Preclinical |
| CHEMBL4752559 | 10.12 | IC50 | 0.075 | Preclinical |
| CHEMBL4757064 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL4784029 | 9.72 | IC50 | 0.19 | Preclinical |
| CHEMBL4741570 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL4761454 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL4787488 | 9.57 | IC50 | 0.27 | Preclinical |
| CHEMBL4750152 | 9.46 | IC50 | 0.35 | Preclinical |
| CHEMBL3760062 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL4747825 | 9.37 | IC50 | 0.43 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 39 | 376 | 6.5 |
| single protein format | 16 | 317 | 6.3 |
| assay format | 3 | 49 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 0 | — |