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Target Snapshot

CHEMBL3724 Target Snapshot

Lysophosphatidic acid receptor 2 · SINGLE PROTEIN · Homo sapiens

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289Compounds
64Assays
0Approved Drugs
350.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9HBW0. Use UniProt Q9HBW0 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9HBW0 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Lysophosphatidic acid receptor 2 as ChEMBL target CHEMBL3724, mapped to UniProt Q9HBW0. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Lysophosphatidic acid receptor 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3724
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9HBW0
Lysophosphatidic acid receptor 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Lysophosphatidic acid receptor 2 is the right protein anchor across sources, using UniProt Q9HBW0 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameLysophosphatidic acid receptor 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9HBW0
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelLysophosphatidic acid receptor 2
UniProt AccessionQ9HBW0
Component TypeProtein
Sequence Length348 aa

Lysophosphatidic acid receptor 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Lysophosphatidic acid receptor 2, mapped to UniProt Q9HBW0. Sequence length is 348 aa.

Mapped IDQ9HBW0
Review nameLysophosphatidic acid receptor 2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50228.0
KI13.0
EC50108.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3322513 9.82 EC50 0.15 Preclinical
CHEMBL5397550 9.6 IC50 0.2512 Preclinical
CHEMBL5395244 9.55 IC50 0.2818 Preclinical
CHEMBL5424571 9.48 IC50 0.3311 Preclinical
CHEMBL5424662 9.46 IC50 0.3467 Preclinical
CHEMBL5434096 9.35 IC50 0.4467 Preclinical
CHEMBL5427161 9.24 IC50 0.5754 Preclinical
CHEMBL5405450 9.22 IC50 0.6026 Preclinical
CHEMBL5393777 9.12 IC50 0.7586 Preclinical
CHEMBL5424251 9.02 IC50 0.955 Preclinical
Distribution

pChEMBL Value Distribution

31
5.0
32
5.5
22
6.0
34
6.5
17
7.0
14
7.5
10
8.0
4
8.5
8
9.0
3
9.5
pChEMBL
Assay Landscape

Assay Landscape

64
Total Assays
112
Tested Compounds
2
Assay Types
Functional — 43 assays, 112 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 38 104 6.3
assay format 4 7 6.5
single protein format 1 1 6.0
Binding — 21 assays, 62 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 13 10 7.2
cell-based format 8 52 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine