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Target Snapshot

CHEMBL373 Target Snapshot

Canis familiaris · ORGANISM · Canis lupus familiaris

Back to Search Search this target Browse approvals Evidence Card
9,378Compounds
16,332Assays
12Approved Drugs
420.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Canis familiaris as ChEMBL target CHEMBL373. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Canis familiaris
ORGANISM · Canis lupus familiaris
As of 2026-09-13
ChEMBL target ID
CHEMBL373
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Canis familiaris still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameCanis familiaris
Target TypeORGANISM
OrganismCanis lupus familiaris
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCanis familiaris
UniProt AccessionN/A

Canis familiaris

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Canis familiaris.

Review nameCanis familiaris
OrganismCanis lupus familiaris
Clinical Profile

Clinical Phase Distribution

12
Approved
4
Phase III
5
Phase II
Assay Mix

Activity Type Distribution

IC50136.0
KI1.0
EC50207.0
KD76.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL603358 10.11 EC50 0.078 Preclinical
CHEMBL477 9.92 EC50 0.12 Approved
CHEMBL2093995 9.74 EC50 0.18 Preclinical
CHEMBL2093996 9.66 EC50 0.22 Preclinical
CHEMBL603362 9.64 EC50 0.23 Preclinical
CHEMBL605239 9.62 EC50 0.24 Preclinical
CHEMBL341686 9.57 Kd 0.2692 Preclinical
CHEMBL507506 9.55 EC50 0.28 Preclinical
CHEMBL836 9.54 Kd 0.2884 Approved
CHEMBL2093997 9.44 EC50 0.36 Preclinical
Distribution

pChEMBL Value Distribution

38
5.0
45
5.5
38
6.0
41
6.5
37
7.0
28
7.5
34
8.0
22
8.5
11
9.0
8
9.5
pChEMBL
Approved Drugs

Approved Drugs

ETRASIMOD
CHEMBL3358920
Approved 2023
Properties Compare Identifier
ALFUZOSIN
CHEMBL709
Approved 2003
Properties Compare Identifier
TAMSULOSIN
CHEMBL836
Approved 1997
Properties Compare Identifier
SUMATRIPTAN
CHEMBL128
Approved 1992
Properties Compare Identifier
DOXAZOSIN
CHEMBL707
Approved 1990
Properties Compare Identifier
ADENOSINE
CHEMBL477
Approved 1989
Properties Compare Identifier
TERAZOSIN
CHEMBL611
Approved 1987
Properties Compare Identifier
MILRINONE
CHEMBL189
Approved 1987
Properties Compare Identifier
NITROGLYCERIN
CHEMBL730
Approved 1981
Properties Compare Identifier
PROPRANOLOL
CHEMBL27
Approved 1967
Properties Compare Identifier
Assay Landscape

Assay Landscape

16,339
Total Assays
274
Tested Compounds
4
Assay Types
ADME — 9,435 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 9,416 9 8.3
assay format 19 0 —
Functional — 6,091 assays, 274 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 6,085 274 6.6
tissue-based format 6 0 —
Toxicity — 809 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 790 0 —
assay format 19 0 —
Unassigned — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 4 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine