Muscarinic acetylcholine receptor M1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt P12657. Use UniProt P12657 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P12657 as the stable identity anchor, then attach disease evidence before program review.
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptor M1, mapped to UniProt P12657. Sequence length is 460 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Muscarinic acetylcholine receptor M1 as ChEMBL target CHEMBL3733, mapped to UniProt P12657. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Muscarinic acetylcholine receptor M1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P12657 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Muscarinic acetylcholine receptor M1 |
| UniProt Accession | P12657 |
| Component Type | Protein |
| Sequence Length | 460 aa |
Muscarinic acetylcholine receptor M1
Review this target as Muscarinic acetylcholine receptor M1, mapped to UniProt P12657. Sequence length is 460 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL12378 | 9.23 | Ki | 0.589 | Preclinical |
| CHEMBL277014 | 8.64 | Ki | 2.31 | Preclinical |
| CHEMBL542065 | 8.54 | Ki | 2.88 | Preclinical |
| CHEMBL7303 | 8.48 | Ki | 3.33 | Preclinical |
| CHEMBL542064 | 8.04 | Ki | 9.01 | Preclinical |
| CHEMBL542559 | 7.81 | Ki | 15.5 | Preclinical |
| CHEMBL21284 | 7.76 | Ki | 17.4 | Preclinical |
| CHEMBL14 | 7.7 | Ki | 19.9 | Approved |
| CHEMBL538467 | 7.63 | Ki | 23.6 | Preclinical |
| CHEMBL7634 | 6.57 | EC50 | 270.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 9 | 21 | 6.6 |
| tissue-based format | 5 | 32 | 5.8 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 3 | 0 | — |