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Target Snapshot

CHEMBL3734641 Target Snapshot

Prolyl endopeptidase FAP · SINGLE PROTEIN · Bos taurus

28Compounds
2Assays
0Approved Drugs
27.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt A5D7B7. Use UniProt A5D7B7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A5D7B7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Prolyl endopeptidase FAP as ChEMBL target CHEMBL3734641, mapped to UniProt A5D7B7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Prolyl endopeptidase FAP
SINGLE PROTEIN · Bos taurus
As of 2026-09-14
ChEMBL target ID
CHEMBL3734641
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
A5D7B7
Prolyl endopeptidase FAP
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Prolyl endopeptidase FAP is the right protein anchor across sources, using UniProt A5D7B7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProlyl endopeptidase FAP
UniProt AccessionA5D7B7
Component TypeProtein
Sequence Length760 aa

Prolyl endopeptidase FAP

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Prolyl endopeptidase FAP, mapped to UniProt A5D7B7. Sequence length is 760 aa.

Mapped IDA5D7B7
Review nameProlyl endopeptidase FAP
OrganismBos taurus
Assay Mix

Activity Type Distribution

IC5027.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3734999 5.42 IC50 3800.0 Preclinical
CHEMBL3736137 5.2 IC50 6300.0 Preclinical
CHEMBL3734769 5.06 IC50 8800.0 Preclinical
CHEMBL3735843 4.85 IC50 14000.0 Preclinical
CHEMBL3735694 4.8 IC50 16000.0 Preclinical
CHEMBL3735917 4.7 IC50 20000.0 Preclinical
CHEMBL3734964 4.66 IC50 22000.0 Preclinical
CHEMBL3645492 4.58 IC50 26000.0 Preclinical
CHEMBL3735925 4.57 IC50 27000.0 Preclinical
CHEMBL3734828 4.5 IC50 32000.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

2
Total Assays
19
Tested Compounds
2
Assay Types
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 0
Binding — 1 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 19 4.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine