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Target Snapshot

CHEMBL3739251 Target Snapshot

Zinc metalloproteinase dpy-31 · SINGLE PROTEIN · Teladorsagia circumcincta

5Compounds
1Assays
0Approved Drugs
5.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-15

Protein identity stays anchored to UniProt A0A0C5PRQ1. Use UniProt A0A0C5PRQ1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt A0A0C5PRQ1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-15
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Zinc metalloproteinase dpy-31 as ChEMBL target CHEMBL3739251, mapped to UniProt A0A0C5PRQ1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Zinc metalloproteinase dpy-31
SINGLE PROTEIN · Teladorsagia circumcincta
As of 2026-09-15
ChEMBL target ID
CHEMBL3739251
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-15
www.ebi.ac.uk
UniProt accession
A0A0C5PRQ1
Zinc metalloproteinase dpy-31
UniProt accession via ChEMBL component mapping As of 2026-09-15
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-15
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Zinc metalloproteinase dpy-31 is the right protein anchor across sources, using UniProt A0A0C5PRQ1 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelZinc metalloproteinase dpy-31
UniProt AccessionA0A0C5PRQ1
Component TypeProtein
Sequence Length614 aa

Zinc metalloproteinase dpy-31

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Zinc metalloproteinase dpy-31, mapped to UniProt A0A0C5PRQ1. Sequence length is 614 aa.

Mapped IDA0A0C5PRQ1
Review nameZinc metalloproteinase dpy-31
OrganismTeladorsagia circumcincta
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC505.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3740110 4.6 IC50 25118.86 Preclinical
CHEMBL3740431 4.5 IC50 31622.78 Preclinical
CHEMBL226853 4.4 IC50 39810.72 Preclinical
CHEMBL279785 4.1 IC50 79432.82 Clinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
4
Tested Compounds
1
Assay Types
Binding — 1 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 4 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine