Poly [ADP-ribose] polymerase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt P11103. Use UniProt P11103 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P11103 as the stable identity anchor, then attach disease evidence before program review.
Poly [ADP-ribose] polymerase 1
Review this target as Poly [ADP-ribose] polymerase 1, mapped to UniProt P11103. Sequence length is 1013 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Poly [ADP-ribose] polymerase 1 as ChEMBL target CHEMBL3740, mapped to UniProt P11103. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Poly [ADP-ribose] polymerase 1 is the right protein anchor across sources, using UniProt P11103 as the stable mapping.
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| Preferred Name | Poly [ADP-ribose] polymerase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | P11103 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Poly [ADP-ribose] polymerase 1 |
| UniProt Accession | P11103 |
| Component Type | Protein |
| Sequence Length | 1013 aa |
Poly [ADP-ribose] polymerase 1
Review this target as Poly [ADP-ribose] polymerase 1, mapped to UniProt P11103. Sequence length is 1013 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3606021 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3698977 | 7.89 | Kd | 13.0 | Preclinical |
| CHEMBL3698978 | 7.7 | Kd | 20.0 | Preclinical |
| CHEMBL3698976 | 7.6 | Kd | 25.0 | Preclinical |
| CHEMBL3698999 | 7.48 | Kd | 33.0 | Preclinical |
| CHEMBL3606015 | 7.47 | Kd | 34.0 | Preclinical |
| CHEMBL3605985 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL3605996 | 7.4 | Kd | 40.0 | Preclinical |
| CHEMBL3606005 | 7.4 | Kd | 40.0 | Preclinical |
| CHEMBL3698979 | 7.4 | Kd | 40.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 76 | 6.2 |
| cell-based format | 4 | 24 | 6.0 |