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Target Snapshot

CHEMBL3745587 Target Snapshot

Suppressor of tumorigenicity 14 protein homolog · SINGLE PROTEIN · Mus musculus

12Compounds
1Assays
0Approved Drugs
12.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P56677. Use UniProt P56677 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P56677 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Suppressor of tumorigenicity 14 protein homolog as ChEMBL target CHEMBL3745587, mapped to UniProt P56677. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Suppressor of tumorigenicity 14 protein homolog
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3745587
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P56677
Suppressor of tumorigenicity 14 protein homolog
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Suppressor of tumorigenicity 14 protein homolog is the right protein anchor across sources, using UniProt P56677 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSuppressor of tumorigenicity 14 protein homolog
UniProt AccessionP56677
Component TypeProtein
Sequence Length855 aa

Suppressor of tumorigenicity 14 protein homolog

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Suppressor of tumorigenicity 14 protein homolog, mapped to UniProt P56677. Sequence length is 855 aa.

Mapped IDP56677
Review nameSuppressor of tumorigenicity 14 protein homolog
OrganismMus musculus
Assay Mix

Activity Type Distribution

KI12.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3745775 8.1 Ki 8.0 Preclinical
CHEMBL3356589 7.98 Ki 10.4 Preclinical
CHEMBL3747468 7.96 Ki 11.1 Preclinical
CHEMBL3747482 7.95 Ki 11.3 Preclinical
CHEMBL3746517 6.75 Ki 177.0 Preclinical
CHEMBL404190 6.64 Ki 227.0 Preclinical
CHEMBL3747618 6.61 Ki 246.0 Preclinical
CHEMBL3747575 6.48 Ki 334.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
1
6.0
3
6.5
0
7.0
3
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
8
Tested Compounds
1
Assay Types
Binding — 1 assays, 8 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 8 7.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine