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Target Snapshot

CHEMBL3746 Target Snapshot

11-beta-hydroxysteroid dehydrogenase type 2 · SINGLE PROTEIN · Homo sapiens

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1,031Compounds
125Assays
0Approved Drugs
638.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P80365. Use UniProt P80365 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P80365 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 11-beta-hydroxysteroid dehydrogenase type 2 as ChEMBL target CHEMBL3746, mapped to UniProt P80365. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
11-beta-hydroxysteroid dehydrogenase type 2
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3746
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P80365
11-beta-hydroxysteroid dehydrogenase type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 11-beta-hydroxysteroid dehydrogenase type 2 is the right protein anchor across sources, using UniProt P80365 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred Name11-beta-hydroxysteroid dehydrogenase type 2
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP80365
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label11-beta-hydroxysteroid dehydrogenase type 2
UniProt AccessionP80365
Component TypeProtein
Sequence Length405 aa

11-beta-hydroxysteroid dehydrogenase type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 11-beta-hydroxysteroid dehydrogenase type 2, mapped to UniProt P80365. Sequence length is 405 aa.

Mapped IDP80365
Review name11-beta-hydroxysteroid dehydrogenase type 2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase III
4
Phase II
Assay Mix

Activity Type Distribution

IC50631.0
KI3.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL441687 9.4 IC50 0.4 Clinical
CHEMBL441687 9.0 EC50 1.0 Clinical
CHEMBL230006 8.92 IC50 1.2 Clinical
CHEMBL1269273 8.54 IC50 2.9 Preclinical
CHEMBL373257 8.52 IC50 3.0 Preclinical
CHEMBL1271410 8.31 IC50 4.9 Preclinical
CHEMBL1761313 8.12 IC50 7.5 Preclinical
CHEMBL597481 8.0 IC50 10.0 Preclinical
CHEMBL1689172 7.96 IC50 11.0 Preclinical
CHEMBL1689280 7.96 IC50 11.0 Preclinical
Distribution

pChEMBL Value Distribution

31
5.0
28
5.5
21
6.0
14
6.5
6
7.0
8
7.5
3
8.0
6
8.5
4
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

125
Total Assays
168
Tested Compounds
2
Assay Types
Binding — 120 assays, 168 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 54 107 5.2
cell-based format 51 60 6.6
assay format 9 0 —
microsome format 6 1 4.8
ADME — 5 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 0 —
cell-based format 2 1 6.8
single protein format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine