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Target Snapshot

CHEMBL3764 Target Snapshot

Urotensin-2 receptor · SINGLE PROTEIN · Homo sapiens

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748Compounds
121Assays
0Approved Drugs
927.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9UKP6. Use UniProt Q9UKP6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9UKP6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Urotensin-2 receptor as ChEMBL target CHEMBL3764, mapped to UniProt Q9UKP6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Urotensin-2 receptor
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3764
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9UKP6
Urotensin-2 receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Urotensin-2 receptor is the right protein anchor across sources, using UniProt Q9UKP6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameUrotensin-2 receptor
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ9UKP6
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelUrotensin-2 receptor
UniProt AccessionQ9UKP6
Component TypeProtein
Sequence Length389 aa

Urotensin-2 receptor

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Urotensin-2 receptor, mapped to UniProt Q9UKP6. Sequence length is 389 aa.

Mapped IDQ9UKP6
Review nameUrotensin-2 receptor
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC50286.0
KI354.0
EC50281.0
KD6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3315139 9.7 Ki 0.1995 Preclinical
CHEMBL390094 9.7 Ki 0.1995 Preclinical
CHEMBL218994 9.6 Ki 0.2512 Preclinical
CHEMBL426020 9.6 Ki 0.2512 Preclinical
CHEMBL504097 9.55 Ki 0.2818 Preclinical
CHEMBL453587 9.52 Ki 0.3 Preclinical
CHEMBL255509 9.4 Ki 0.4 Preclinical
CHEMBL257171 9.4 Ki 0.4 Preclinical
CHEMBL3315142 9.4 Ki 0.3981 Preclinical
CHEMBL4777970 9.35 EC50 0.45 Preclinical
Distribution

pChEMBL Value Distribution

40
5.0
118
5.5
131
6.0
143
6.5
132
7.0
109
7.5
91
8.0
51
8.5
19
9.0
12
9.5
pChEMBL
Assay Landscape

Assay Landscape

121
Total Assays
500
Tested Compounds
3
Assay Types
Binding — 66 assays, 500 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 44 470 7.1
single protein format 22 30 7.8
Functional — 54 assays, 259 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 48 249 6.8
assay format 6 10 6.6
Toxicity — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 1 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine