Neprilysin · SINGLE PROTEIN · Oryctolagus cuniculus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P08049. Use UniProt P08049 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P08049 as the stable identity anchor, then attach disease evidence before program review.
Neprilysin
Review this target as Neprilysin, mapped to UniProt P08049. Sequence length is 750 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neprilysin as ChEMBL target CHEMBL3768, mapped to UniProt P08049. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Neprilysin is the right protein anchor across sources, using UniProt P08049 as the stable mapping.
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| Preferred Name | Neprilysin |
| Target Type | SINGLE PROTEIN |
| Organism | Oryctolagus cuniculus |
| UniProt | P08049 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neprilysin |
| UniProt Accession | P08049 |
| Component Type | Protein |
| Sequence Length | 750 aa |
Neprilysin
Review this target as Neprilysin, mapped to UniProt P08049. Sequence length is 750 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL303159 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL66967 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL479579 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL1907967 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL285490 | 9.15 | Ki | 0.7 | Preclinical |
| CHEMBL225085 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL1159952 | 9.03 | Ki | 0.94 | Preclinical |
| CHEMBL304939 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL329125 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL66284 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 24 | 287 | 7.7 |
| assay format | 3 | 8 | 8.2 |