Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial · SINGLE PROTEIN · Sus scrofa
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As of 2026-09-15Protein identity stays anchored to UniProt P29804. Use UniProt P29804 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P29804 as the stable identity anchor, then attach disease evidence before program review.
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Review this target as Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, mapped to UniProt P29804. Sequence length is 389 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial as ChEMBL target CHEMBL3774302, mapped to UniProt P29804. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Sus scrofa |
| UniProt | P29804 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial |
| UniProt Accession | P29804 |
| Component Type | Protein |
| Sequence Length | 389 aa |
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial
Review this target as Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial, mapped to UniProt P29804. Sequence length is 389 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5419102 | 8.35 | Ki | 4.45 | Preclinical |
| CHEMBL5417802 | 8.3 | Ki | 4.95 | Preclinical |
| CHEMBL5420203 | 7.76 | Ki | 17.5 | Preclinical |
| CHEMBL401772 | 7.75 | Ki | 18.0 | Preclinical |
| CHEMBL5440127 | 7.59 | Ki | 25.5 | Preclinical |
| CHEMBL5271689 | 7.52 | Ki | 30.0 | Preclinical |
| CHEMBL5408769 | 7.5 | Ki | 31.5 | Preclinical |
| CHEMBL5417344 | 7.41 | Ki | 39.0 | Preclinical |
| CHEMBL5290932 | 7.4 | Ki | 40.0 | Preclinical |
| CHEMBL5268763 | 7.35 | Ki | 45.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 11 | 19 | 6.1 |