Caspase-8 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Caspase-8 shows clinical signal disease relevance led by hepatitis C virus infection. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q14790. Start with hepatitis C virus infection, then reuse UniProt Q14790 as the stable protein anchor across project notes and exports.
Start with hepatitis C virus infection, then reuse UniProt Q14790 as the stable protein anchor across project notes and exports.
Caspase-8 shows clinical signal disease relevance led by hepatitis C virus infection. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with hepatitis C virus infection because it currently carries clinical signal support. Linked drugs include NIVOCASAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyCaspase-8
Review this target as Caspase-8, mapped to UniProt Q14790. Sequence length is 479 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Caspase-8 as ChEMBL target CHEMBL3776, mapped to UniProt Q14790. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Caspase-8 is the right protein anchor across sources, using UniProt Q14790 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why hepatitis C virus infection is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Caspase-8 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14790 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Caspase-8 |
| UniProt Accession | Q14790 |
| Component Type | Protein |
| Sequence Length | 479 aa |
Caspase-8
Review this target as Caspase-8, mapped to UniProt Q14790. Sequence length is 479 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Caspase-8 shows clinical signal disease relevance led by hepatitis C virus infection. 1 more disease program remain visible in the same review block.
Start review with hepatitis C virus infection because it currently carries clinical signal support. Linked drugs include NIVOCASAN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5569363 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL5723373 | 9.04 | Ki | 0.92 | Preclinical |
| CHEMBL5822466 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3934331 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL91281 | 8.89 | Ki | 1.3 | Preclinical |
| CHEMBL5723323 | 8.8 | Ki | 1.6 | Preclinical |
| CHEMBL315868 | 8.72 | Ki | 1.9 | Preclinical |
| CHEMBL194207 | 8.68 | Ki | 2.1 | Preclinical |
| CHEMBL3914770 | 8.6 | Ki | 2.5 | Preclinical |
| CHEMBL3917557 | 8.59 | Ki | 2.6 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 89 | 312 | 6.4 |
| assay format | 9 | 42 | 5.3 |
| cell-based format | 5 | 0 | — |
| biochemical format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 4 | 8.6 |
| cell-based format | 5 | 5 | — |