NACHT, LRR and PYD domains-containing protein 3 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-13Protein identity stays anchored to UniProt Q8R4B8. Use UniProt Q8R4B8 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8R4B8 as the stable identity anchor, then attach disease evidence before program review.
NACHT, LRR and PYD domains-containing protein 3
Review this target as NACHT, LRR and PYD domains-containing protein 3, mapped to UniProt Q8R4B8. Sequence length is 1033 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NACHT, LRR and PYD domains-containing protein 3 as ChEMBL target CHEMBL3779755, mapped to UniProt Q8R4B8. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | NACHT, LRR and PYD domains-containing protein 3 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q8R4B8 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NACHT, LRR and PYD domains-containing protein 3 |
| UniProt Accession | Q8R4B8 |
| Component Type | Protein |
| Sequence Length | 1033 aa |
NACHT, LRR and PYD domains-containing protein 3
Review this target as NACHT, LRR and PYD domains-containing protein 3, mapped to UniProt Q8R4B8. Sequence length is 1033 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5184952 | 9.64 | IC50 | 0.23 | Preclinical |
| CHEMBL3183703 | 9.41 | IC50 | 0.39 | Preclinical |
| CHEMBL3989943 | 9.0 | IC50 | 1.0 | Clinical |
| CHEMBL5421905 | 8.16 | IC50 | 6.88 | Preclinical |
| CHEMBL4288808 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL5422387 | 8.07 | IC50 | 8.58 | Preclinical |
| CHEMBL4650350 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL5396485 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL5597392 | 7.82 | IC50 | 15.29 | Preclinical |
| CHEMBL5436366 | 7.7 | IC50 | 19.9 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 285 | 361 | 6.0 |
| tissue-based format | 45 | 46 | 5.2 |
| single protein format | 30 | 20 | 6.0 |
| subcellular format | 24 | 0 | — |
| assay format | 9 | 5 | 6.1 |