Receptor-interacting serine/threonine-protein kinase 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt Q60855. Use UniProt Q60855 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q60855 as the stable identity anchor, then attach disease evidence before program review.
Receptor-interacting serine/threonine-protein kinase 1
Review this target as Receptor-interacting serine/threonine-protein kinase 1, mapped to UniProt Q60855. Sequence length is 656 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Receptor-interacting serine/threonine-protein kinase 1 as ChEMBL target CHEMBL3784911, mapped to UniProt Q60855. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Receptor-interacting serine/threonine-protein kinase 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | Q60855 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Receptor-interacting serine/threonine-protein kinase 1 |
| UniProt Accession | Q60855 |
| Component Type | Protein |
| Sequence Length | 656 aa |
Receptor-interacting serine/threonine-protein kinase 1
Review this target as Receptor-interacting serine/threonine-protein kinase 1, mapped to UniProt Q60855. Sequence length is 656 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4100398 | 8.57 | IC50 | 2.7 | Preclinical |
| CHEMBL4545939 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL4092421 | 7.57 | EC50 | 27.0 | Preclinical |
| CHEMBL4514271 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL3109202 | 7.3 | IC50 | 50.0 | Preclinical |
| CHEMBL4100398 | 7.09 | Ki | 81.28 | Preclinical |
| CHEMBL4549667 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL3785703 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL4445751 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL4455611 | 6.72 | Ki | 189.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 20 | 26 | 6.2 |
| single protein format | 5 | 7 | 6.4 |
| assay format | 1 | 1 | 6.2 |