Serine/threonine-protein kinase PLK4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Serine/threonine-protein kinase PLK4 shows clinical signal disease relevance led by neoplasm. 3 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt O00444. Start with neoplasm, then reuse UniProt O00444 as the stable protein anchor across project notes and exports.
Start with neoplasm, then reuse UniProt O00444 as the stable protein anchor across project notes and exports.
Serine/threonine-protein kinase PLK4 shows clinical signal disease relevance led by neoplasm. 3 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include OCIFISERTIB, RG-1530. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySerine/threonine-protein kinase PLK4
Review this target as Serine/threonine-protein kinase PLK4, mapped to UniProt O00444. Sequence length is 970 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine/threonine-protein kinase PLK4 as ChEMBL target CHEMBL3788, mapped to UniProt O00444. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Serine/threonine-protein kinase PLK4 is the right protein anchor across sources, using UniProt O00444 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why neoplasm is currently framed as clinical signal support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Serine/threonine-protein kinase PLK4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O00444 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine/threonine-protein kinase PLK4 |
| UniProt Accession | O00444 |
| Component Type | Protein |
| Sequence Length | 970 aa |
Serine/threonine-protein kinase PLK4
Review this target as Serine/threonine-protein kinase PLK4, mapped to UniProt O00444. Sequence length is 970 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Serine/threonine-protein kinase PLK4 shows clinical signal disease relevance led by neoplasm. 3 more disease programs remain visible in the same review block.
Start review with neoplasm because it currently carries clinical signal support. Linked drugs include OCIFISERTIB, RG-1530. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3408945 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL5209160 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL5185225 | 9.8 | Ki | 0.16 | Preclinical |
| CHEMBL5185001 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL3408947 | 9.59 | Ki | 0.26 | Clinical |
| CHEMBL5171469 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5404983 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL5428085 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL2407898 | 9.49 | IC50 | 0.32 | Preclinical |
| CHEMBL3353348 | 9.43 | IC50 | 0.37 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 217 | 348 | 7.3 |
| assay format | 32 | 78 | 7.4 |
| cell-based format | 20 | 5 | 7.4 |
| subcellular format | 6 | 43 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 306 | 6.5 |