Histone deacetylase 8 · SINGLE PROTEIN · Schistosoma mansoni
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As of 2026-09-14Protein identity stays anchored to UniProt A5H660. Use UniProt A5H660 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt A5H660 as the stable identity anchor, then attach disease evidence before program review.
histone deacetylase
Review this target as Histone deacetylase 8, mapped to UniProt A5H660. ChEMBL maps the protein component as histone deacetylase. Sequence length is 440 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 8 as ChEMBL target CHEMBL3797017, mapped to UniProt A5H660. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone deacetylase 8 is the right protein anchor across sources, using UniProt A5H660 as the stable mapping.
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| Preferred Name | Histone deacetylase 8 |
| Target Type | SINGLE PROTEIN |
| Organism | Schistosoma mansoni |
| UniProt | A5H660 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | histone deacetylase |
| UniProt Accession | A5H660 |
| Component Type | Protein |
| Sequence Length | 440 aa |
histone deacetylase
Review this target as Histone deacetylase 8, mapped to UniProt A5H660. ChEMBL maps the protein component as histone deacetylase. Sequence length is 440 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2105763 | 7.55 | Kd | 28.4 | Clinical |
| CHEMBL3797843 | 7.17 | IC50 | 67.0 | Preclinical |
| CHEMBL3800394 | 7.12 | IC50 | 75.4 | Preclinical |
| CHEMBL2178342 | 7.09 | Kd | 81.7 | Preclinical |
| CHEMBL3799246 | 7.04 | IC50 | 91.2 | Preclinical |
| CHEMBL2178342 | 7.02 | IC50 | 95.4 | Preclinical |
| CHEMBL3798183 | 7.02 | IC50 | 95.5 | Preclinical |
| CHEMBL4160522 | 7.01 | IC50 | 97.0 | Preclinical |
| CHEMBL4853162 | 7.0 | IC50 | 100.0 | Preclinical |
| CHEMBL4855490 | 7.0 | IC50 | 100.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 8 | 99 | 6.2 |
| assay format | 2 | 42 | 6.4 |
| cell-based format | 2 | 5 | 6.8 |