Review anchor
Human immunodeficiency virus 2
ORGANISM · Human immunodeficiency virus 2
As of 2026-09-13
Evidence Snapshot
Human immunodeficiency virus 2
CHEMBL380
ORGANISM
Human immunodeficiency virus 2
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Human immunodeficiency virus 2 as ChEMBL target CHEMBL380. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL380
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-13
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Human immunodeficiency virus 2 matters
Human immunodeficiency virus 2 is reviewed as Human immunodeficiency virus 2; the current evidence base includes 44 approved drugs, 4266 compounds, and 428 assays, with lead potency reaching pChEMBL 11.0.
Protein context
Human immunodeficiency virus 2
Human immunodeficiency virus 2
Review this target as Human immunodeficiency virus 2.
Protein source · UniProt accession via ChEMBL component mappingDisease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 44 approved drugs, 4266 compounds, and 428 assays for this target. The dominant activity type is EC50. CHEMBL57548 is the current potency anchor at pChEMBL 11.0.
Use CHEMBL57548 as the tractability anchor when discussing potency (pChEMBL 11.0).
Activity source · ChEMBL 36 via Core Engine
44 approved
pChEMBL 11.0
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Human immunodeficiency virus 2 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
4266
Total Compounds
428
Total Assays
44
Approved Drugs
IC50: 774.0, KI: 2.0, EC50: 3932.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL57548
|
11.0 | IC50 | — |
|
|
No preferred name
CHEMBL513181
|
10.7 | EC50 | — |
|
|
No preferred name
CHEMBL5398494
|
10.7 | EC50 | — |
|
|
No preferred name
CHEMBL267571
|
10.6 | Ki | — |
|
|
No preferred name
CHEMBL104245
|
10.4 | EC50 | — |
Approved Drugs
| Structure | Compound | First Approval |
|---|---|---|
|
|
DOLUTEGRAVIR SODIUM
CHEMBL1213165
|
2013 |
|
|
TOFACITINIB
CHEMBL221959
|
2012 |
|
|
ELVITEGRAVIR
CHEMBL204656
|
2012 |
|
|
RUXOLITINIB
CHEMBL1789941
|
2011 |
|
|
INGENOL MEBUTATE
CHEMBL1863513
|
2010 |
|
|
PLERIXAFOR
CHEMBL18442
|
2008 |
|
|
ETRAVIRINE
CHEMBL308954
|
2008 |
|
|
RALTEGRAVIR
CHEMBL254316
|
2007 |
|
|
RALTEGRAVIR POTASSIUM
CHEMBL518520
|
2007 |
|
|
DARUNAVIR
CHEMBL1323
|
2006 |
|
|
TIPRANAVIR
CHEMBL222559
|
2005 |
|
|
EMTRICITABINE
CHEMBL885
|
2003 |
|
|
ENFUVIRTIDE
CHEMBL525076
|
2003 |
|
|
ATAZANAVIR
CHEMBL1163
|
2003 |
|
|
ADEFOVIR DIPIVOXIL
CHEMBL922
|
2002 |
|
|
TENOFOVIR DISOPROXIL
CHEMBL1538
|
2001 |
|
|
TENOFOVIR DISOPROXIL FUMARATE
CHEMBL1486
|
2001 |
|
|
LOPINAVIR
CHEMBL729
|
2000 |
|
|
AMPRENAVIR
CHEMBL116
|
1999 |
|
|
EFAVIRENZ
CHEMBL223228
|
1998 |
|
|
NELFINAVIR
CHEMBL584
|
1997 |
|
|
RITONAVIR
CHEMBL163
|
1996 |
|
|
LAMIVUDINE
CHEMBL141
|
1995 |
|
|
SAQUINAVIR
CHEMBL114
|
1995 |
|
|
STAVUDINE
CHEMBL991
|
1994 |
|
|
ZALCITABINE
CHEMBL853
|
1992 |
|
|
ZIDOVUDINE
CHEMBL129
|
1987 |
Source Header